(6-Methoxypyridin-3-yl)boronic acid → 1'-[(5-chloro-2-thienyl)methyl]-5-(6-methoxypyridin-3-yl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 1128942Notes

Reaction equation

HRID 1128942 reaction equation
[Br:24][c:25]1[cH:26][cH:27][c:28]2[c:29]([cH:49]1)[C:30]1([CH2:31][O:32]2)[C:33](=[O:48])[N:34]([CH2:41][c:42]2[s:43][c:44]([Cl:47])[cH:45][cH:46]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]21.[Br:50][c:51]1[cH:52][cH:53][cH:54][c:55]2[c:78]1[C:66]1([C:64](=[O:65])[N:56]2[CH2:57][c:58]2[s:59][c:60]([Cl:61])[cH:62][cH:63]2)[c:67]2[cH:68][c:69]3[c:73]([cH:74][c:75]2[O:76][CH2:77]1)[O:72][CH2:71][O:70]3.[CH3:12][N:13]([CH3:14])[c:15]1[n:16][cH:17][c:18]([B:19]([OH:20])[OH:21])[cH:22][cH:23]1.[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([B:9]([OH:10])[OH:11])[cH:7][n:8]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6](-[c:25]2[cH:26][cH:27][c:28]3[c:29]([cH:49]2)[C:30]2([CH2:31][O:32]3)[C:33](=[O:48])[N:34]([CH2:41][c:42]3[s:43][c:44]([Cl:47])[cH:45][cH:46]3)[c:35]3[cH:36][cH:37][cH:38][cH:39][c:40]32)[cH:7][n:8]1

Participants

5

Reactant 4

HCID 2734368(6-Methoxypyridin-3-yl)boronic acidHCID 27632716-(Dimethylamino)pyridine-3-boronic acidHCID 119980755-bromo-1'-[(5-chloro-2-thienyl)methyl]spiro[1-benzofuran-3,3'-indol]-2'(1'H)-oneHCID 593525614'-bromo-1'-[(5-chloro-2-thienyl)methyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 593527821'-[(5-chloro-2-thienyl)methyl]-5-(6-methoxypyridin-3-yl)spiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-8a25ad0b9318469abba1759714f9f4d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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