6-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acid → N-(1-cyclopropyl-3-hydroxy-3-methylbutan-2-yl)-6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)pyridine-2-carboxamide

HRID 1129122Notes

Reaction equation

HRID 1129122 reaction equation
[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:13])[OH:14])[n:11]2)[CH2:2][CH2:3]1.[NH2:21][CH:22]([C:23]([CH3:24])([OH:25])[CH3:26])[CH2:27][CH:28]1[CH2:29][CH2:30]1>>[CH:1]1([CH2:4][O:5][c:6]2[c:7]([N:15]3[CH2:16][C:17]([F:19])([F:20])[CH2:18]3)[cH:8][cH:9][c:10]([C:12](=[O:14])[NH:21][CH:22]([C:23]([CH3:24])([OH:25])[CH3:26])[CH2:27][CH:28]3[CH2:29][CH2:30]3)[n:11]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 710872926-(Cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)picolinic acidHCID 836818403-Amino-4-cyclopropyl-2-methylbutan-2-ol

Product 1

HCID 78010121N-(1-cyclopropyl-3-hydroxy-3-methylbutan-2-yl)-6-(cyclopropylmethoxy)-5-(3,3-difluoroazetidin-1-yl)pyridine-2-carboxamide

Sources & evidence

ORD record
ord-b23f4f990e34473484bdf829b5e3e27a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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