Diethyl [4-({4-[(7-bromo-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)amino]-5(trifluoromethyl)pyrimidin-2-yl}amino)benzyl]phosphonate → Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate
Reaction equation
[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH2:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:36]([F:37])([F:38])[F:39])[c:21]([NH:23][c:24]3[c:25]4[c:29]([c:30]([Br:33])[cH:31][cH:32]3)[CH2:28][N:27]([CH3:34])[C:26]4=[O:35])[n:22]2)[cH:14][cH:15]1.[CH3:40][C:41]1([CH3:42])[C:43]([CH3:44])([CH3:45])[O:46][B:47]([c:48]2[cH:49][n:50][n:51]([CH2:53][CH2:54][CH2:55][OH:56])[cH:52]2)[O:57]1>>[CH2:1]([CH3:2])[O:3][P:4]([O:5][CH2:6][CH3:7])(=[O:8])[CH2:9][c:10]1[cH:11][cH:12][c:13]([NH:16][c:17]2[n:18][cH:19][c:20]([C:36]([F:37])([F:38])[F:39])[c:21]([NH:23][c:24]3[c:25]4[c:29]([c:30](-[c:48]5[cH:49][n:50][n:51]([CH2:53][CH2:54][CH2:55][OH:56])[cH:52]5)[cH:31][cH:32]3)[CH2:28][N:27]([CH3:34])[C:26]4=[O:35])[n:22]2)[cH:14][cH:15]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-c991f814bdb94093b16a28ab0207ce63
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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