HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4'-amino-3'-methylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 10566894 | — |
| Reactant | 3-Methylpiperidin-4-amine | HCID 11815842 | — |
| Product | 5-Amino-1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-7-(4'-amino-3'-methylpiperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid | HCID 10158087 | 50% |
Reaction Steps
The condensation of 5-amino-1-cyclopropyl-6,7-difluoro-8-methoxy -1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 4-amino-3-methylpiperidine was carried out in a similar manner as described in example 1, gave the titled product. Yield 50%, m.p 260–62° C., C20H25FN4O4, m/z 405 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098219B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-a04fa00654814628b99f27e75b65df65 |
| Source note | uspto-grants-2006_08 |