HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 5-Amino-1-(cyclopropyl)-6,8-difluoro-1,4-dihydro-7-(3'-aminomethyl-4'-hydroxy-piperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1-cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 13910947 | — |
| Reactant | 3-(Aminomethyl)piperidin-4-ol | HCID 21615388 | — |
| Product | 5-Amino-1-(cyclopropyl)-6,8-difluoro-1,4-dihydro-7-(3'-aminomethyl-4'-hydroxy-piperidin-1-yl)-4-oxo-quinoline-3-carboxylic acid | HCID 86760218 | 52.8% |
Reaction Steps
The condensation of 5-amino-1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-aminomethyl-4-hydroxy-piperidine was carried out in a similar manner as described in example 1, gave the titled product. Yield 52.8%, m.p 202–04° C., C19H22F2N4O4, m/z 409 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098219B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-db8fe1955bfb44b1ad634f8887301c0b |
| Source note | uspto-grants-2006_08 |