Methanol → Tert-butyl 2-(2-amino-1-hydroxy-3-phenylpropyl)pyrrolidine-1-carboxylate

HRID 1129978Notes

Reaction equation

HRID 1129978 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:13]([CH:14]([CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[N:22]([CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:30][c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[OH:37])[CH2:10][CH2:11][CH2:12]1.[CH3:40][OH:41].[H:38][H:39].[OH-:42].[OH-:44].[Pd+2:43]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH:13]([CH:14]([CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[NH2:22])[OH:37])[CH2:10][CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 21054748Tert-butyl 2-[2-(dibenzylamino)-1-hydroxy-3-phenylpropyl]pyrrolidine-1-carboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 68815267Tert-butyl 2-(2-amino-1-hydroxy-3-phenylpropyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-c180a80b94954bada25f43ba11a48bb0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…