1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid → HCID 10270754, compound

HRID 11301Notes

Reaction equation

HRID 11301 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11](F)[N:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.[NH2:20][CH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH:22]1[CH2:27][CH3:28]>C(#N)C>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([N:24]4[CH2:25][CH2:26][CH:21]([NH2:20])[CH:22]([CH2:27][CH3:28])[CH2:23]4)[N:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 151930221-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acidHCID 219737733-Ethylpiperidin-4-amine

Product 1

HCID 10270754HCID 10270754, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The condensation of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-naphthyridine-3-carboxylic acid with 4-amino-3-ethylpiperidine was carried out in acetonitrile in a similar manner as described in example 1, gave the titled product. Yield 71%, m.p 218–20° C., C19H23FN4O3, m/z 375 (M+1).

Sources & evidence

ORD record
ord-7048ad1dcc504833a6fca74d13f1cf65
Source dataset
uspto-grants-2006_08
Patent number
US07098219B2

Reaction notes

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