Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1130225Generated: November 2, 2026

1,4-Dioxane → 4-{2-[(3,5-Bis-trifluoromethyl-phenyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-pyrimidin-5-yloxy}-butyric acid

https://huagongshe.com/reaction/1130225

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DioxaneHCID 31275—
ReactantTert-butyl 4-{2-[(3,5-bis-trifluoromethyl-phenyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-pyrimidin-5-yloxy}-butyrateHCID 86626893—
Product4-{2-[(3,5-Bis-trifluoromethyl-phenyl)-(5'-isopropyl-2'-methoxy-4-trifluoromethyl-biphenyl-2-ylmethyl)-amino]-pyrimidin-5-yloxy}-butyric acidHCID 86626894—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
ORD IDord-df2bb2225a564f54b46e8213bcd9062e
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (7/10)