Ammonia → N-{5-[5-(2-Amino-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

HRID 1130242Notes

Reaction equation

HRID 1130242 reaction equation
[CH3:35][OH:36].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:33])[c:20]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[cH:27][c:28]([F:32])[cH:29][cH:30][cH:31]4)[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1.[NH3:34]>>[c:2]1([NH2:34])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[cH:17][cH:18][c:19]([F:33])[c:20]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[cH:27][c:28]([F:32])[cH:29][cH:30][cH:31]4)[cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 57989802N-{5-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

Product 1

HCID 57989798N-{5-[5-(2-Amino-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-3-fluorobenzenesulfonamide

Sources & evidence

ORD record
ord-905a4d1da8d3406a9e4fd541d5570e4c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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