Morpholine → 1'-[(5-morpholin-4-ylpyridin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

HRID 1130340Notes

Reaction equation

HRID 1130340 reaction equation
[Br:20][c:21]1[cH:22][cH:23][c:24]([CH2:27][N:28]2[C:29](=[O:49])[C:30]3([CH2:31][O:32][c:33]4[cH:34][c:35]5[c:36]([cH:41][c:42]43)[O:37][CH2:38][CH2:39][O:40]5)[c:43]3[cH:44][cH:45][cH:46][cH:47][c:48]32)[n:25][cH:26]1.[Br:50][c:51]1[cH:52][cH:53][c:54]([CH2:55][N:56]2[c:57]3[c:58]([cH:59][cH:60][cH:61][cH:62]3)[C:63]3([c:64]4[cH:65][c:66]([F:67])[c:68]([F:69])[cH:70][c:71]4[O:72][CH2:73]3)[C:74]2=[O:75])[cH:76][cH:77]1.[C:7]([N:8]1[CH2:9][CH2:10][CH:11]([NH2:12])[CH2:13]1)([O:14][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19].[CH2:1]1[CH2:2][O:3][CH2:4][CH2:5][NH:6]1>>[CH2:1]1[CH2:2][O:3][CH2:4][CH2:5][N:6]1[c:21]1[cH:22][cH:23][c:24]([CH2:27][N:28]2[C:29](=[O:49])[C:30]3([CH2:31][O:32][c:33]4[cH:34][c:35]5[c:36]([cH:41][c:42]43)[O:37][CH2:38][CH2:39][O:40]5)[c:43]3[cH:44][cH:45][cH:46][cH:47][c:48]32)[n:25][cH:26]1

Participants

5

Reactant 4

HCID 8083MorpholineHCID 27563701-Boc-3-aminopyrrolidineHCID 593524831'-(4-bromobenzyl)-5,6-difluorospiro[1-benzofuran-3,3'-indol]-2'(1'H)-oneHCID 59352743HCID 59352743, compound

Product 1

HCID 593522091'-[(5-morpholin-4-ylpyridin-2-yl)methyl]-2,3-dihydrospiro[furo[2,3-g][1,4]benzodioxine-8,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-b680aaff4b524a3a9fbfa3158fe9727c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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