1,4-Dibromo-2-butanol → N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamide

HRID 1130357Notes

Reaction equation

HRID 1130357 reaction equation
[Br:27][CH2:28][CH:29]([CH2:30][CH2:31][Br:32])[OH:33].[NH2:1][CH:2]1[CH:3]([NH:8][C:9]([c:10]2[c:11]([O:24][CH3:25])[cH:12][c:13]([C:20]([F:21])([F:22])[F:23])[cH:14][c:15]2[C:16]([F:17])([F:18])[F:19])=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7]1>>[N:1]1([CH:2]2[CH:3]([NH:8][C:9]([c:10]3[c:11]([O:24][CH3:25])[cH:12][c:13]([C:20]([F:21])([F:22])[F:23])[cH:14][c:15]3[C:16]([F:17])([F:18])[F:19])=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7]2)[CH2:28][CH:29]([OH:33])[CH2:30][CH2:31]1

Participants

3

Reactant 2

HCID 295701,4-Dibromo-2-butanolHCID 76682998N-(2-aminocyclohexyl)-2-methoxy-4,6-bis(trifluoromethyl)benzamide

Product 1

HCID 76682981N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Sources & evidence

ORD record
ord-f88fe981c7694b4fa12995c8cd3cfed1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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