Dimethyl Sulfoxide → 1'-[2-Chloro-5-(methyloxy)-4-nitrophenyl]-1,4'-bipiperidine

HRID 1130816Notes

Reaction equation

HRID 1130816 reaction equation
[CH3:1][O:2][c:3]1[c:4]([N+:11](=[O:12])[O-:13])[cH:5][c:6]([Cl:10])[c:7]([F:9])[cH:8]1.[CH3:33][S:34]([CH3:35])=[O:36].[K+:14].[K+:15].[N:20]1([CH:26]2[CH2:27][CH2:28][NH:29][CH2:30][CH2:31]2)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1.[O-:16][C:17]([O-:18])=[O:19].[OH2:32]>>[CH3:1][O:2][c:3]1[c:4]([N+:11](=[O:12])[O-:13])[cH:5][c:6]([Cl:10])[c:7]([N:29]2[CH2:28][CH2:27][CH:26]([N:20]3[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]3)[CH2:31][CH2:30]2)[cH:8]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 786071,4'-BipiperidineHCID 534032891-Chloro-2-fluoro-4-methoxy-5-nitrobenzene

Product 1

HCID 594529741'-[2-Chloro-5-(methyloxy)-4-nitrophenyl]-1,4'-bipiperidine

Sources & evidence

ORD record
ord-a28c89ab0320458b9c977b362c8bd582
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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