2-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridine → N-[6-(3-Azabicyclo[3.1.0]hex-3-yl)pyridin-3-yl]-5-trifluoromethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

HRID 1131132Notes

Reaction equation

HRID 1131132 reaction equation
[CH:25]12[CH2:26][N:27]([c:31]3[cH:32][cH:33][c:34]([NH2:37])[cH:35][n:36]3)[CH2:28][CH:29]1[CH2:30]2.[F:1][C:2]([c:3]1[cH:4][c:5]2[c:6]([n:7][cH:8]1)[n:9]([CH2:15][c:16]1[cH:17][c:18]([F:22])[cH:19][cH:20][cH:21]1)[c:10]([C:12](=[O:13])[OH:14])[cH:11]2)([F:23])[F:24]>>[F:1][C:2]([c:3]1[cH:4][c:5]2[c:6]([n:7][cH:8]1)[n:9]([CH2:15][c:16]1[cH:17][c:18]([F:22])[cH:19][cH:20][cH:21]1)[c:10]([C:12](=[O:13])[NH:37][c:34]1[cH:33][cH:32][c:31]([N:27]3[CH2:26][CH:25]4[CH:29]([CH2:28]3)[CH2:30]4)[n:36][cH:35]1)[cH:11]2)([F:23])[F:24]

Participants

3

Reactant 2

HCID 574315312-(3-Azabicyclo[3.1.0]hex-3-yl)-5-aminopyridineHCID 668635175-Trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

Product 1

HCID 66907801N-[6-(3-Azabicyclo[3.1.0]hex-3-yl)pyridin-3-yl]-5-trifluoromethyl-1-(3-fluorobenzyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Sources & evidence

ORD record
ord-92b70007d00246899cc98de887b33d02
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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