Acetic Acid → methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate

HRID 1131308Notes

Reaction equation

HRID 1131308 reaction equation
[C:37]([OH:38])(=[O:39])[CH3:40].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10](-[c:15]2[n:16]([CH3:34])[c:17]3[cH:18][c:19]([C:30](=[O:31])[O:32][CH3:33])[cH:20][cH:21][c:22]3[c:23]2[CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[cH:11][cH:12][cH:13][cH:14]1.[CH3:35][OH:36].[OH-:41].[OH-:43].[Pd+2:42]>>[OH:8][c:9]1[c:10](-[c:15]2[n:16]([CH3:34])[c:17]3[cH:18][c:19]([C:30](=[O:31])[O:32][CH3:33])[cH:20][cH:21][c:22]3[c:23]2[CH:24]2[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]2)[cH:11][cH:12][cH:13][cH:14]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 58317811methyl 2-[2-(benzyloxy)phenyl]-3-cyclohexyl-1-methyl-1H-indole-6-carboxylate

Product 1

HCID 58317807methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1-methyl-1H-indole-6-carboxylate

Sources & evidence

ORD record
ord-f9c52234387b4eac832dd5a6e9956771
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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