Ethanol → 3-[2-(3-{[tert-Butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-4-(hydroxymethyl)-1-oxo-1,2-dihydroisoquinolin-6-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide
Reaction equation
[BH4-:1].[C:3]([CH3:4])([CH3:5])([CH3:6])[Si:7]([O:8][CH2:9][C:10]([CH2:11][n:12]1[c:13](=[O:38])[c:14]2[cH:15][cH:16][c:17](-[c:24]3[cH:25][c:26]([C:27](=[O:28])[NH:29][CH:30]4[CH2:31][CH2:32]4)[cH:33][c:34]([F:37])[c:35]3[CH3:36])[cH:18][c:19]2[c:20]([CH:22]=[O:23])[cH:21]1)([CH3:39])[CH3:40])([CH3:41])[CH3:42].[CH3:48][CH2:49][OH:50].[Na+:2].[Na+:47].[O-:43][C:44]([OH:45])=[O:46]>>[C:3]([CH3:4])([CH3:5])([CH3:6])[Si:7]([O:8][CH2:9][C:10]([CH2:11][n:12]1[c:13](=[O:38])[c:14]2[cH:15][cH:16][c:17](-[c:24]3[cH:25][c:26]([C:27](=[O:28])[NH:29][CH:30]4[CH2:31][CH2:32]4)[cH:33][c:34]([F:37])[c:35]3[CH3:36])[cH:18][c:19]2[c:20]([CH2:22][OH:23])[cH:21]1)([CH3:39])[CH3:40])([CH3:41])[CH3:42]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-03ff2107a6ad431b91fc6cd0f22282d8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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