Ethyl 4-Chloroquinoline-3-carboxylate → Ethyl 4-chloro-6,7-difluoroquinoline-3-carboxylate
Reaction equation
[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7][cH:8]2)[n:9][cH:10][c:11]1[C:12]([O:13][CH2:14][CH3:15])=[O:16].[F:17][c:18]1[cH:19][c:20]2[c:21]([OH:34])[c:22]([C:29](=[O:30])[O:31][CH2:32][CH3:33])[cH:23][n:24][c:25]2[cH:26][c:27]1[F:28]>>[Cl:1][c:21]1[c:20]2[cH:19][c:18]([F:17])[c:27]([F:28])[cH:26][c:25]2[n:24][cH:23][c:22]1[C:29](=[O:30])[O:31][CH2:32][CH3:33]Participants
3
Sources & evidence
- ORD record
- ord-5a29ecafd5b14c73b7621821ebbd2b57
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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