Methanol → 2-Amino-5-(p-iodobenzyl)aminomethylpyrrolo[2,3-d]pyrimidin-4-one

HRID 1131631Notes

Reaction equation

[BH4-:26].[CH3:23][O-:24].[CH3:28][OH:29].[I:14][c:15]1[cH:16][cH:17][c:18]([CH:19]=[O:20])[cH:21][cH:22]1.[NH2:1][C:2]1=[N:3][C:4](=[O:13])[C:5]2=[C:10]([CH2:11][NH2:12])[CH:9]=[N:8][C:6]2=[N:7]1.[Na+:25].[Na+:27]>>[NH2:1][C:2]1=[N:3][C:4](=[O:13])[C:5]2=[C:10]([CH2:11][NH:12][CH2:19][c:18]3[cH:17][cH:16][c:15]([I:14])[cH:22][cH:21]3)[CH:9]=[N:8][C:6]2=[N:7]1

Participants

Reactant 6

HCID 887Methanol

HCID 923Sodium ion2×

HCID 28123Borohydride

HCID 966574-Iodobenzaldehyde

HCID 3826051Methoxide

HCID 202463772-Amino-5-aminomethylpyrrolo[2,3-d]pyrimidin-4-one

Product 1

HCID 204685712-Amino-5-(p-iodobenzyl)aminomethylpyrrolo[2,3-d]pyrimidin-4-one

Sources & evidence

ORD record: ord-a53fc94308cd4419a6198ad920821107
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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