Methanol → tert-butyl (1RS,2RS)-2-hydroxy-2-(2-phenyl-1,3-thiazol-4-yl)-1-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]ethylcarbamate

HRID 1132016Notes

Reaction equation

HRID 1132016 reaction equation
[CH3:41][OH:42].[Na+:40].[O:1]=[C:2]1[O:3][CH:4]([c:28]2[n:29][c:30](-[c:33]3[cH:34][cH:35][cH:36][cH:37][cH:38]3)[s:31][cH:32]2)[CH:5]([CH2:14][c:15]2[cH:16][c:17]([O:21][C:22]([CH:23]([F:24])[F:25])([F:26])[F:27])[cH:18][cH:19][cH:20]2)[N:6]1[C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13].[OH-:39].[OH2:43]>>[OH:3][CH:4]([CH:5]([NH:6][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:14][c:15]1[cH:16][c:17]([O:21][C:22]([CH:23]([F:24])[F:25])([F:26])[F:27])[cH:18][cH:19][cH:20]1)[c:28]1[n:29][c:30](-[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[s:31][cH:32]1

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 86593307tert-butyl (4RS,5RS)-2-oxo-5-(2-phenyl-1,3-thiazol-4-yl)-4-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-1,3-oxazolidine-3-carboxylate

Product 1

HCID 86593308tert-butyl (1RS,2RS)-2-hydroxy-2-(2-phenyl-1,3-thiazol-4-yl)-1-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]ethylcarbamate

Sources & evidence

ORD record
ord-ea0c655a0f774769b81bedcb742490fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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