Methanol → 2-hydroxy-N-[5-(2-hydroxyethyl)-2-oxo-3,4-dihydro-1H-1,5-benzodiazepin-3-yl]-2-methyl-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide

HRID 1132185Notes

Reaction equation

HRID 1132185 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][N:11]1[c:12]2[c:13]([cH:36][cH:37][cH:38][cH:39]2)[NH:14][C:15](=[O:35])[CH:16]([NH:18][C:19]([C:20]([C:21](=[O:22])[NH:23][CH2:24][C:25]([C:26]([F:27])([F:28])[F:29])([F:30])[F:31])([CH3:32])[OH:33])=[O:34])[CH2:17]1.[CH3:42][OH:43].[H:40][H:41]>>[OH:8][CH2:9][CH2:10][N:11]1[c:12]2[c:13]([cH:36][cH:37][cH:38][cH:39]2)[NH:14][C:15](=[O:35])[CH:16]([NH:18][C:19]([C:20]([C:21](=[O:22])[NH:23][CH2:24][C:25]([C:26]([F:27])([F:28])[F:29])([F:30])[F:31])([CH3:32])[OH:33])=[O:34])[CH2:17]1

Participants

4

Reactant 3

HCID 887MethanolHCID 744124952-hydroxy-2-methyl-N-[2-oxo-5-(2-phenylmethoxyethyl)-3,4-dihydro-1H-1,5-benzodiazepin-3-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamideHCID 178418361HCID 178418361, compound

Product 1

HCID 743266722-hydroxy-N-[5-(2-hydroxyethyl)-2-oxo-3,4-dihydro-1H-1,5-benzodiazepin-3-yl]-2-methyl-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide

Sources & evidence

ORD record
ord-62ab36fafda043c18a09d51ca545b37c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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