2-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol → N-Cyclopropyl-3-(2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzamide

HRID 113246Notes

Reaction equation

HRID 113246 reaction equation
[Cl:23][c:24]1[cH:25][c:26]([N:31]2[CH2:32][CH2:33][N:34]([CH2:37][CH2:38][OH:39])[CH2:35][CH2:36]2)[n:27][c:28]([CH3:30])[n:29]1.[NH2:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([C:14](=[O:15])[NH:16][CH:17]3[CH2:18][CH2:19]3)[cH:20][cH:21][cH:22]1)[cH:9][s:10]2>>[NH:1]([c:2]1[n:3][cH:4][c:5]2[c:6]([n:7]1)[c:8](-[c:11]1[cH:12][c:13]([C:14](=[O:15])[NH:16][CH:17]3[CH2:18][CH2:19]3)[cH:20][cH:21][cH:22]1)[cH:9][s:10]2)[c:24]1[cH:25][c:26]([N:31]2[CH2:32][CH2:33][N:34]([CH2:37][CH2:38][OH:39])[CH2:35][CH2:36]2)[n:27][c:28]([CH3:30])[n:29]1

Participants

3

Reactant 2

HCID 144795582-(4-(6-Chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanolHCID 671201443-(2-aminothieno[3,2-d]pyrimidin-7-yl)-N-cyclopropylbenzamide

Product 1

HCID 52931895N-Cyclopropyl-3-(2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thieno[3,2-d]pyrimidin-7-yl)benzamide

Sources & evidence

ORD record
ord-beba555dcf18457c96b7da7a875d0819
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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