Ammonia → (R)-2-(5-methyl-1-(pyridin-2-yl)-1H-pyrazol-4-yl)-6-(2-(2-methylpyrrolidin-1-yl)ethyl)quinoline

Participants

Reaction Steps

The title compound was prepared using the procedure described in Example 1G using 1-(5-methyl-1-pyridin-2-yl-1H-pyrazol-4-yl)-ethanone (Singh, S. P., et. al. Heterocycl. Commun., 2001, 7(1), p. 49-54) for 1-(4-methyl-2-thiophen-2-yl-thiazol-5-yl)-ethanone. 1H NMR (300 MHz, CDCl3) δ 1.14 (d, J=6.10 Hz, 3H), 1.46 (m, 1H), 1.77 (m, 2H), 1.96 (m, 1H), 2.25 (q, J=8.82 Hz, 1H), 2.40 (m, 2H), 3.01 (m, 2H), 3.06 (s, 3H), 3.13 (m, 1H), 3.30 (td, J=8.56, 2.54 Hz, 1H), 7.26 (m, 1H), 7.61 (m, 3H), 7.87 (m, 2H), 8.03 (d, J=8.48 Hz, 1H), 8.11 (d, J=8.82 Hz, 1H), 8.13 (s, 1H), 8.53 (m, 1H); MS (DCI-NH3) [M+H]+ at 398.

Provenance & Evidence