Ammonia → HCID 11554762, compound

HRID 11328Notes

Reaction equation

HRID 11328 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([CH3:17])[N:8]=2)[N:5]=[CH:4][C:3]=1[C:18](=O)[CH3:19].[CH3:21][C:22]1[N:23]=[C:24]([C:30]2S[CH:32]=[CH:33][CH:34]=2)S[C:26]=1[C:27](=O)[CH3:28].[NH3:35]>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[C:9]([CH3:17])[N:8]=2)[N:5]=[CH:4][C:3]=1[C:18]1[CH:19]=[CH:18][C:3]2[C:2](=[CH:32][CH:33]=[C:34]([CH2:30][CH2:24][N:23]3[CH2:28][CH2:27][CH2:26][C@H:22]3[CH3:21])[CH:4]=2)[N:35]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 27442451-[4-Methyl-2-(2-thienyl)-1,3-thiazol-5-yl]-1-ethanoneHCID 28060241-[5-methyl-1-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-ethanone

Product 1

HCID 11554762HCID 11554762, compound

Procedure

The title compound was prepared using the procedure described in Example 1G using 1-[5-methyl-1-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-1H-pyrazol-4-yl]-ethanone (Maybridge Chemical Company Ltd., catalog number CD 11385) for 1-(4-methyl-2-thiophen-2-yl-thiazol-5-yl)-ethanone. 1H NMR (300 MHz, CDCl3) δ 1.15 (d, J=6.10 Hz, 3H), 1.49 (m, 1H), 1.79 (m, 2H), 1.96 (m, 1H), 2.27 (m, 1H), 2.43 (m, 2H), 2.68 (s, 3H), 3.05 (m, 2H), 3.11 (s, 3H), 3.15 (m, 1H), 3.32 (m, 1H), 7.30 (s, 1H), 7.61 (m, 3H), 8.01 (s, 1H), 8.03 (d, J=8.48 Hz, 1H), 8.12 (d, J=8.14 Hz, 1H), 8.14 (s, 1H); MS (DCI-NH3) [M+H]+ at 480.

Sources & evidence

ORD record
ord-3307087b8d5d40d38070035323b7feac
Source dataset
uspto-grants-2006_08
Patent number
US07098222B2

Reaction notes

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