Ammonia → HCID 11632711, compound

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	1-(2-Phenyl-1,3-thiazol-5-yl)ethan-1-one	HCID 608996	—
Reactant	1-[4-Methyl-2-(2-thienyl)-1,3-thiazol-5-yl]-1-ethanone	HCID 2744245	—
Product	HCID 11632711	HCID 11632711	—

Reaction Steps

The title compound was prepared using the procedure described in Example 1G substituting 1-(2-phenyl-thiazol-5-yl)-ethanone (Arcadi, A., et al. Eur. J. Org. Chem. 1999, 11, p. 3117-3126) for 1-(4-methyl-2-thiophen-2-yl-thiazol-5-yl)-ethanone. 1H NMR (300 MHz, CDCl3) δ 1.13 (d, J=6.10 Hz, 3H), 1.46 (m, 1H), 1.78 (m, 2H), 1.95 (m, 1H), 2.24 (q, J=8.82 Hz, 1H), 2.39 (m, 2H), 3.01 (m, 2H), 3.13 (m, 1H), 3.29 (td, J=8.48, 2.71 Hz, 1H), 7.47 (m, 3H), 7.61 (m, 2H), 7.81 (d, J=8.48 Hz, 1H), 8.03 (m, 3H), 8.12 (d, J=8.48 Hz, 1H), 8.38 (s, 1H); MS (DCI-NH3) [M+H]+ at 400.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07098222B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-6f7702eb948c4c2facbd472fb7cfe693
Source note	uspto-grants-2006_08