1,4-Dichloro-5,6,7,8-tetrahydrophthalazine → 4-chloro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-5,6,7,8-tetrahydrophthalazin-1-amine

HRID 1132957Notes

Reaction equation

HRID 1132957 reaction equation
[Cl:1][c:2]1[n:3][n:4][c:5]([Cl:12])[c:6]2[c:11]1[CH2:10][CH2:9][CH2:8][CH2:7]2.[NH2:13][c:14]1[cH:15][cH:16][c:17]([O:18][c:19]2[n:20][cH:21][cH:22][cH:23][c:24]2-[c:25]2[n:26][c:27]([NH:31][CH3:32])[n:28][cH:29][cH:30]2)[cH:33][cH:34]1>>[c:2]1([NH:13][c:14]2[cH:15][cH:16][c:17]([O:18][c:19]3[n:20][cH:21][cH:22][cH:23][c:24]3-[c:25]3[n:26][c:27]([NH:31][CH3:32])[n:28][cH:29][cH:30]3)[cH:33][cH:34]2)[n:3][n:4][c:5]([Cl:12])[c:6]2[c:11]1[CH2:10][CH2:9][CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 126224401,4-Dichloro-5,6,7,8-tetrahydrophthalazineHCID 469295414-(2-(4-aminophenoxy)pyridin-3-yl)-N-methylpyrimidin-2-amine

Product 1

HCID 577562304-chloro-N-(4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-5,6,7,8-tetrahydrophthalazin-1-amine

Sources & evidence

ORD record
ord-57cb7c3fa2fa4ef5b6322ff1c0172729
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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