Tert-butyl 2-[(5-amino-2-chlorophenoxy)methyl]pyrrolidine-1-carboxylate → Tert-butyl 2-[[2-chloro-5-[[7-(3-methylsulfonylphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenoxy]methyl]pyrrolidine-1-carboxylate

HRID 1133203Notes

Reaction equation

HRID 1133203 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:13][O:14][c:15]2[c:16]([Cl:22])[cH:17][cH:18][c:19]([NH2:21])[cH:20]2)[CH2:10][CH2:11][CH2:12]1.[CH3:23][S:24](=[O:25])(=[O:26])[c:27]1[cH:28][c:29](-[c:33]2[cH:34][cH:35][c:36]3[cH:37][n:38][c:39]([OH:42])[n:40][n:41]23)[cH:30][cH:31][cH:32]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([CH2:13][O:14][c:15]2[c:16]([Cl:22])[cH:17][cH:18][c:19]([NH:21][c:39]3[n:38][cH:37][c:36]4[cH:35][cH:34][c:33](-[c:29]5[cH:28][c:27]([S:24]([CH3:23])(=[O:25])=[O:26])[cH:32][cH:31][cH:30]5)[n:41]4[n:40]3)[cH:20]2)[CH2:10][CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 66711633Tert-butyl 2-[(5-amino-2-chlorophenoxy)methyl]pyrrolidine-1-carboxylateHCID 178504720HCID 178504720, compound

Product 1

HCID 66711975Tert-butyl 2-[[2-chloro-5-[[7-(3-methylsulfonylphenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenoxy]methyl]pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-845a2299ee734fc2a32753562b82d000
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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