反应详情

Tert-butyl 4-[(2,3-dimethyl-5-nitro-6-phenoxypyridin-4-yl)amino]butylcarbamate (9.17 g, 21.3 mmol), toluene (50 mL), isopropanol (5 mL) and 5% platinum on carbon (7.0 g) were combined and maintained under hydrogen pressure (50 psi, 3.5 Kg/cm2) overnight on a Parr apparatus. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. The resulting brown oil was dried under high vacuum to provide 7.47 g of tert-butyl 4-[(3-amino-5,6-dimethyl-2-phenoxypyridin-4-yl)amino]butylcarbamate.

1. temperaturemaintained under hydrogen pressure (50 psi, 3.5 Kg/cm2) overnight on a Parr apparatus
2. customThe catalyst was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting brown oil was dried under high vacuum