4-(Chloromethyl)benzonitrile → Ethyl 5-(3-(4-cyanobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate

HRID 1134998Notes

Reaction equation

HRID 1134998 reaction equation
[Br:1][CH2:2][CH2:3][O:4][Si:5]([C:6]([CH3:7])([CH3:8])[CH3:9])([CH3:10])[CH3:11].[CH3:22][c:23]1[c:24]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[s:25][c:26]([N:28]2[C:29](=[O:33])[NH:30][CH2:31][CH2:32]2)[cH:27]1.[Cl:12][CH2:13][c:14]1[cH:15][cH:16][c:17]([C:18]#[N:19])[cH:20][cH:21]1>>[CH2:13]([c:14]1[cH:15][cH:16][c:17]([C:18]#[N:19])[cH:20][cH:21]1)[N:30]1[C:29](=[O:33])[N:28]([c:26]2[s:25][c:24]([C:34](=[O:35])[O:36][CH2:37][CH3:38])[c:23]([CH3:22])[cH:27]2)[CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 701274-(Chloromethyl)benzonitrileHCID 3608067(2-Bromoethoxy)-tert-butyldimethylsilaneHCID 58031554Ethyl 3-methyl-5-(2-oxoimidazolidin-1-yl)thiophene-2-carboxylate

Product 1

HCID 58031419Ethyl 5-(3-(4-cyanobenzyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate

Sources & evidence

ORD record
ord-5dd522915cff4553be982d8d909d42d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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