(6-Aminopyridin-3-yl)boronic acid → 2-(4-((2-(6-Aminopyridin-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

HRID 1135241Notes

Reaction equation

HRID 1135241 reaction equation
[Cl:1][c:2]1[n:3][c:4]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][N:13]1[CH2:14][CH2:15][N:16]([C:19]([C:20](=[O:21])[NH2:22])([CH3:23])[CH3:24])[CH2:17][CH2:18]1)[n:11]2.[NH2:31][c:32]1[n:33][cH:34][c:35]([B:38]([OH:39])[OH:40])[cH:36][cH:37]1>>[c:2]1(-[c:35]2[cH:34][n:33][c:32]([NH2:31])[cH:37][cH:36]2)[n:3][c:4]([N:25]2[CH2:26][CH2:27][O:28][CH2:29][CH2:30]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][N:13]1[CH2:14][CH2:15][N:16]([C:19]([C:20](=[O:21])[NH2:22])([CH3:23])[CH3:24])[CH2:17][CH2:18]1)[n:11]2

Participants

3

Reactant 2

HCID 22396308(6-Aminopyridin-3-yl)boronic acidHCID 584049422-(4-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

Product 1

HCID 533784682-(4-((2-(6-Aminopyridin-3-yl)-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-methylpropanamide

Sources & evidence

ORD record
ord-ad4935192db44985ad80b8d23d0b802f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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