Methanol → 3-Amino-5-fluorobenzoic acid

HRID 1135758Notes

Reaction equation

HRID 1135758 reaction equation
[CH3:19][OH:20].[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][c:9]([N+:11]([O-:12])=[O:13])[cH:10]1.[H:14][H:15].[OH-:16].[OH-:17].[Pd+2:18]>>[F:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][c:9]([NH2:11])[cH:10]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27590473-Fluoro-5-nitrobenzoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 179151483-Amino-5-fluorobenzoic acid

Sources & evidence

ORD record
ord-7823706cf1574ffabc7187e8bdcd7058
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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