6-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazine → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(2-furyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

HRID 1136227Notes

Reaction equation

HRID 1136227 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9](-[c:11]1[o:12][cH:13][cH:14][cH:15]1)[n:10]2.[NH2:16][c:17]1[s:18][c:19](-[c:25]2[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]2[F:31])[cH:20][c:21]1[C:22](=[O:23])[NH2:24]>>[c:2]1([NH:16][c:17]2[s:18][c:19](-[c:25]3[c:26]([F:36])[cH:27][c:28]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:29][c:30]3[F:31])[cH:20][c:21]2[C:22](=[O:23])[NH2:24])[cH:3][cH:4][c:5]2[n:6]([n:7]1)[cH:8][c:9](-[c:11]1[o:12][cH:13][cH:14][cH:15]1)[n:10]2

Participants

3

Reactant 2

HCID 117461286-Chloro-2-(furan-2-yl)imidazo[1,2-b]pyridazineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445527345-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[2-(2-furyl)imidazo[1,2-b]pyridazin-6-yl]amino}thiophene-3-carboxamide

Sources & evidence

ORD record
ord-4a4b4c9a48cc4d6692fb8bfa5335bb37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…