2-Chloro-4-isocyanato-1-(trifluoromethyl)benzene → N-[3-chloro-4-(trifluoromethyl)phenyl]-4-[4-(8-hydroxy-6-azaspiro[2.5]octan-6-yl)-4-oxobutyl]-2-methyl-3-oxopiperazine-1-carboxamide
Reaction equation
[Cl:23][c:24]1[c:25]([C:33]([F:34])([F:35])[F:36])[cH:26][cH:27][c:28]([N:30]=[C:31]=[O:32])[cH:29]1.[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5]2)[CH2:6][CH2:7][N:8]([C:10]([CH2:11][CH2:12][CH2:13][N:14]2[C:15](=[O:21])[CH:16]([CH3:20])[NH:17][CH2:18][CH2:19]2)=[O:22])[CH2:9]1>>[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5]2)[CH2:6][CH2:7][N:8]([C:10]([CH2:11][CH2:12][CH2:13][N:14]2[C:15](=[O:21])[CH:16]([CH3:20])[N:17]([C:31]([NH:30][c:28]3[cH:27][cH:26][c:25]([C:33]([F:34])([F:35])[F:36])[c:24]([Cl:23])[cH:29]3)=[O:32])[CH2:18][CH2:19]2)=[O:22])[CH2:9]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-8fa1ffee482d4711be24323cc43051aa
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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