1-(2-Hydroxyethyl)piperazine → 5-[4,5-bis(4-chlorophenyl)-1-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4,5-dimethylimidazol-2-yl]-N-tert-butyl-2-chloro-4-ethoxybenzenesulfonamide

HRID 1137316Notes

Reaction equation

HRID 1137316 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[c:10]([Cl:42])[cH:11][c:12]([O:39][CH2:40][CH3:41])[c:13]([C:15]2=[N:19][C:18]([CH3:20])([c:21]3[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]3)[C:17]([CH3:28])([c:29]3[cH:30][cH:31][c:32]([Cl:35])[cH:33][cH:34]3)[N:16]2[C:36](=[O:37])[Cl:38])[cH:14]1.[N:43]1([CH2:49][CH2:50][OH:51])[CH2:44][CH2:45][NH:46][CH2:47][CH2:48]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[NH:5][S:6](=[O:7])(=[O:8])[c:9]1[c:10]([Cl:42])[cH:11][c:12]([O:39][CH2:40][CH3:41])[c:13]([C:15]2=[N:19][C:18]([CH3:20])([c:21]3[cH:22][cH:23][c:24]([Cl:27])[cH:25][cH:26]3)[C:17]([CH3:28])([c:29]3[cH:30][cH:31][c:32]([Cl:35])[cH:33][cH:34]3)[N:16]2[C:36](=[O:37])[N:46]2[CH2:45][CH2:44][N:43]([CH2:49][CH2:50][OH:51])[CH2:48][CH2:47]2)[cH:14]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 72455726rac-(4S*,5R*)-2-(5-tert-Butylsulfamoyl-4-chloro-2-ethoxyphenyl)-4,5-bis-(4-chlorophenyl)-4,5-dimethyl-4,5-dihydroimidazole-1-carbonyl chloride

Product 1

HCID 1784666875-[4,5-bis(4-chlorophenyl)-1-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4,5-dimethylimidazol-2-yl]-N-tert-butyl-2-chloro-4-ethoxybenzenesulfonamide

Sources & evidence

ORD record
ord-3e7b137c141f43bf942768eb1ec2795f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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