Potassium Cation → 5-(5-Bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

HRID 1137862Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]([CH:9]([F:10])[F:11])([CH2:12][OH:13])[NH:14][C:15]([CH:16]([CH3:17])[Cl:18])=[O:19])[cH:7]1.[CH3:23][C:24]#[N:25].[K+:22].[OH-:21]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:20])[c:6]([C:8]2([CH:9]([F:10])[F:11])[CH2:12][O:13][CH:16]([CH3:17])[C:15](=[O:19])[NH:14]2)[cH:7]1

Participants

Reactant 4

HCID 813Potassium Cation

HCID 961Hydroxide

HCID 6342Acetonitrile

HCID 66665576N-[1-(5-Bromo-2-fluoro-phenyl)-2,2-difluoro-1-hydroxymethyl-ethyl]-2-chloropropionamide

Product 1

HCID 666659295-(5-Bromo-2-fluoro-phenyl)-5-difluoromethyl-2-methyl-morpholin-3-one

Sources & evidence

ORD record: ord-322e23c5c2104938b42842e6bec64c8d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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