4-Chloro-3-(1-methyl-pyrrolidin-2-ylmethoxy)-phenylamine → N-(2-{2-[4-Chloro-3-(1-methyl-pyrrolidin-2-ylmethoxy)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-N-methyl-methanesulfonamide

HRID 113813Notes

Reaction equation

HRID 113813 reaction equation
[CH3:17][S:18](=[O:19])(=[O:20])[N:21]([c:22]1[c:23](-[c:28]2[cH:29][cH:30][c:31]3[cH:32][n:33][c:34]([O:37][S:38]([C:39]([F:40])([F:41])[F:42])(=[O:43])=[O:44])[n:35][n:36]23)[cH:24][cH:25][cH:26][cH:27]1)[CH3:45].[Cl:1][c:2]1[c:3]([O:9][CH2:10][CH:11]2[N:12]([CH3:16])[CH2:13][CH2:14][CH2:15]2)[cH:4][c:5]([NH2:8])[cH:6][cH:7]1>>[Cl:1][c:2]1[c:3]([O:9][CH2:10][CH:11]2[N:12]([CH3:16])[CH2:13][CH2:14][CH2:15]2)[cH:4][c:5]([NH:8][c:34]2[n:33][cH:32][c:31]3[cH:30][cH:29][c:28](-[c:23]4[c:22]([N:21]([S:18]([CH3:17])(=[O:19])=[O:20])[CH3:45])[cH:27][cH:26][cH:25][cH:24]4)[n:36]3[n:35]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 540900204-Chloro-3-(1-methyl-pyrrolidin-2-ylmethoxy)-phenylamineHCID 86661681Trifluoro-methanesulfonic acid 7-[2-(methanesulfonyl-methyl-amino)-phenyl]-pyrrolo[2,1-f][1,2,4]triazin-2-yl ester

Product 1

HCID 46851867N-(2-{2-[4-Chloro-3-(1-methyl-pyrrolidin-2-ylmethoxy)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-7-yl}-phenyl)-N-methyl-methanesulfonamide

Sources & evidence

ORD record
ord-f2f78861edc549eaa960c28bab2c81d0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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