4-Bromo-3-methyl-isoquinoline → N,N-dimethyl-1-((2-(3-methylisoquinolin-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-amine

HRID 1138315Notes

Reaction equation

HRID 1138315 reaction equation
[Br:39][c:40]1[c:41]([CH3:50])[n:42][cH:43][c:44]2[cH:45][cH:46][cH:47][cH:48][c:49]12.[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14]([Sn:25]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37])[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14](-[c:40]4[c:41]([CH3:50])[n:42][cH:43][c:44]5[cH:45][cH:46][cH:47][cH:48][c:49]45)[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]

Participants

3

Reactant 2

HCID 37777034-Bromo-3-methyl-isoquinolineHCID 59605498Dimethyl-[1-(4-morpholin-4-yl-2-(tributylstannanyl)thieno[3,2-d]pyrimidin-6-ylmethyl)piperidin-4-yl]amine

Product 1

HCID 49832773N,N-dimethyl-1-((2-(3-methylisoquinolin-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-amine

Sources & evidence

ORD record
ord-87664b6d7c264cb8ad248797fa1e5259
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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