HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 69282462, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Chloromethyl)-5-methyl-2-(2-methylphenyl)-1,3-oxazole | HCID 21974258 | — |
| Reactant | Rac-2-ethoxy-3-(1h-indol-4-yl)-propionic acid ethyl ester | HCID 69279879 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 69282462 | HCID 69282462 | — |
Reaction Steps
In analogy to the procedures described in examples 1 a] and 1 b], rac-2-ethoxy-3-(1H-indol-4-yl)-propionic acid ethyl ester was reacted with 4-chloromethyl-5-methyl-2-o-tolyl-oxazole in N,N-dimethylformamide in the presence of sodium hydride to yield rac-2-ethoxy-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-4-yl]-propionic acid ethyl ester, which was subsequently saponified to yield rac-2-ethoxy-3-[1-(5-methyl-2-o-tolyl-oxazol-4-ylmethyl)-1H-indol-4-yl]-propionic acid as light brown oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07098228B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-1b6e7eb10b5f44208e4438dbf1d72dd3 |
| Source note | uspto-grants-2006_08 |