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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1139059Generated: October 31, 2026

Dimethylformamide → (+/-)-2-Amino-1-ethyl-7-(3-hydroxy-3-pyrazin-2-ylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

https://huagongshe.com/reaction/1139059

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantTriethylamineHCID 8471—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant2-(Pyrazin-2-yl)but-3-yn-2-olHCID 58221410—
Reactant2-Amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 86642336—
Product(+/-)-2-Amino-1-ethyl-7-(3-hydroxy-3-pyrazin-2-ylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 67081541—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (7/10)
ORD IDord-ae6f8b2c31bf4882bc449227c0790ff8
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (7/10)