Methyl 5-aminobenzofuran-2-carboxylate → 5-fluoro-N4-(3-isopropylphenyl)-N2-(2-methoxycarbonylbenzofur-5-yl)-2,4-pyrimidinediamine

HRID 1139447Notes

Reaction equation

HRID 1139447 reaction equation
[CH3:19][O:20][C:21](=[O:22])[c:23]1[o:24][c:25]2[c:26]([cH:27]1)[cH:28][c:29]([NH2:32])[cH:30][cH:31]2.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([CH:15]([CH3:16])[CH3:17])[cH:12][cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:32][c:29]2[cH:28][c:26]3[c:25]([o:24][c:23]([C:21]([O:20][CH3:19])=[O:22])[cH:27]3)[cH:31][cH:30]2)[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([CH:15]([CH3:16])[CH3:17])[cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 10845388Methyl 5-aminobenzofuran-2-carboxylateHCID 220603082-chloro-5-fluoro-N4-(3-isopropylphenyl)-4-pyrimidineamine

Product 1

HCID 220604465-fluoro-N4-(3-isopropylphenyl)-N2-(2-methoxycarbonylbenzofur-5-yl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-f2991c6770144999a58702822525bbe9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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