Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-chloro-2-ethyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-(Benzensulfonyl)-5-chloro-2-ethylindole | HCID 21974278 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-chloro-2-ethyl-1H-indole | HCID 20517175 | — |
반응 단계
A mixture of 2 (1.3 g, 4.07 mmol), 2N NaOH (12 mL), and MeOH (62 mL) was refluxed for 40 h. The organic solvent was evaporated and the remaining residue was extracted with EtOAc. The combined extract were washed with brine, dried (Na2SO4) and evaporated in vacuo to give a residue which was purified by flash chromatography (silica gel, cyclohexane/ethyl acetate, 8:2) and crystallization from ether/cyclohexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07098233B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6eb7296ff68e46c49fe21f7b0425c303 |
| 출처 메모 | uspto-grants-2006_08 |