1-Amino-2-cyclopropylpropan-2-ol → 5-Bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

HRID 1140692Notes

Reaction equation

HRID 1140692 reaction equation
[Br:1][c:2]1[c:3]([O:15][CH2:16][C:17]([F:18])([F:19])[F:20])[n:4][c:5]([C:11]([F:12])([F:13])[F:14])[c:6]([C:7](=[O:8])[OH:9])[cH:10]1.[NH2:21][CH2:22][C:23]([OH:24])([CH:25]1[CH2:26][CH2:27]1)[CH3:28]>>[Br:1][c:2]1[c:3]([O:15][CH2:16][C:17]([F:18])([F:19])[F:20])[n:4][c:5]([C:11]([F:12])([F:13])[F:14])[c:6]([C:7](=[O:9])[NH:21][CH2:22][C:23]([OH:24])([CH:25]2[CH2:26][CH2:27]2)[CH3:28])[cH:10]1

Participants

3

Reactant 2

HCID 211096921-Amino-2-cyclopropylpropan-2-olHCID 863463205-Bromo-6-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)nicotinic acid

Product 1

HCID 866347985-Bromo-N-(2-cyclopropyl-2-hydroxy-propyl)-6-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-nicotinamide

Sources & evidence

ORD record
ord-66fd845db3f34ceb91416ad2e301b995
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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