1-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazole → 9-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-(2,2,3,3,3-pentafluoro-propyl)-amide

HRID 1141301Notes

Reaction equation

HRID 1141301 reaction equation
[CH3:30][n:31]1[c:32]([N:40]2[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]2)[n:33][c:34]2[c:35]1[cH:36][cH:37][cH:38][cH:39]2.[F:1][C:2]([CH2:3][NH:4][C:5](=[O:6])[C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][Br:24])[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2-[c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)([C:25]([F:26])([F:27])[F:28])[F:29]>>[F:1][C:2]([CH2:3][NH:4][C:5](=[O:6])[C:7]1([CH2:20][CH2:21][CH2:22][CH2:23][N:43]2[CH2:42][CH2:41][N:40]([c:32]3[n:31]([CH3:30])[c:35]4[c:34]([n:33]3)[cH:39][cH:38][cH:37][cH:36]4)[CH2:45][CH2:44]2)[c:8]2[cH:9][cH:10][cH:11][cH:12][c:13]2-[c:14]2[cH:15][cH:16][cH:17][cH:18][c:19]21)([C:25]([F:26])([F:27])[F:28])[F:29]

Participants

3

Reactant 2

HCID 6675511-methyl-2-(piperazin-1-yl)-1H-benzo[d]imidazoleHCID 226362759-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,3,3,3-pentafluoro-propyl)-amide

Product 1

HCID 226363489-{4-[4-(1-methyl-1H-benzimidazol-2-yl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic Acid-(2,2,3,3,3-pentafluoro-propyl)-amide

Sources & evidence

ORD record
ord-7445ce516ef74741a28d8292174f38fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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