2-(2,5-Dichloropyrimidin-4-ylamino)-N-methylbenzamide → 2-{5-Chloro-2-[3-(2,2-difluoro-propyl)-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-N-methyl-benzamide
Reaction equation
[Cl:20][c:21]1[n:22][cH:23][c:24]([Cl:38])[c:25]([NH:27][c:28]2[c:29]([C:30](=[O:31])[NH:32][CH3:33])[cH:34][cH:35][cH:36][cH:37]2)[n:26]1.[F:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[c:8]([cH:11][c:12]([NH2:17])[c:13]([O:15][CH3:16])[cH:14]2)[CH2:9][CH2:10]1)([CH3:18])[F:19]>>[F:1][C:2]([CH2:3][N:4]1[CH2:5][CH2:6][c:7]2[c:8]([cH:11][c:12]([NH:17][c:21]3[n:22][cH:23][c:24]([Cl:38])[c:25]([NH:27][c:28]4[c:29]([C:30](=[O:31])[NH:32][CH3:33])[cH:34][cH:35][cH:36][cH:37]4)[n:26]3)[c:13]([O:15][CH3:16])[cH:14]2)[CH2:9][CH2:10]1)([CH3:18])[F:19]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-336e60d18f094e5fb11b5b477bc136ce
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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