1-Methyl-1H-indole-7-carboxylic acid → 1-(1-Methyl-7-indolecarbonyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-(phenylhydroxymethyl)pyrrolidine

HRID 1142044Notes

Reaction equation

HRID 1142044 reaction equation
[CH3:28][n:29]1[cH:30][cH:31][c:32]2[cH:33][cH:34][cH:35][c:36]([C:38](=[O:39])[OH:40])[c:37]12.[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]3[CH2:16][NH:17][CH2:18][CH:19]3[CH:20]([OH:21])[c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH:15]3[CH2:16][N:17]([C:38]([c:36]4[cH:35][cH:34][cH:33][c:32]5[cH:31][cH:30][n:29]([CH3:28])[c:37]54)=[O:39])[CH2:18][CH:19]3[CH:20]([OH:21])[c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 183883621-Methyl-1H-indole-7-carboxylic acidHCID 183883753-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(RS)-(phenylhydroxymethyl)pyrrolidine

Product 1

HCID 187235011-(1-Methyl-7-indolecarbonyl)-3-(RS)-(4-(4-fluorophenyl)piperidinylmethyl)-4-(SR)-(phenylhydroxymethyl)pyrrolidine

Sources & evidence

ORD record
ord-b6285120993740309c74773b150809c3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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