2-(Bromomethyl)tetrahydro-2H-pyran → 4'-[6-(dimethylamino)pyridin-3-yl]-1'-{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one
Reaction equation
[Br:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:18]1.[CH3:19][N:20]([c:21]1[cH:22][cH:23][c:24](-[c:27]2[c:28]3[c:29]([cH:30][cH:31][cH:32]2)[NH:33][C:34](=[O:47])[C:35]32[CH2:36][O:37][c:38]3[c:39]2[cH:40][c:41]2[c:42]([cH:46]3)[O:43][CH2:44][O:45]2)[cH:25][n:26]1)[CH3:48].[Cl:1][CH2:2][c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1.[NH:49]1[c:50]2[c:51]([cH:52][cH:53][cH:54][cH:55]2)[C:56]2([CH2:57][O:58][c:59]3[cH:60][c:61]4[c:62]([cH:63][c:64]32)[CH2:65][CH2:66][O:67]4)[C:68]1=[O:69]>>[CH2:2]([c:3]1[n:4][c:5]([CH:8]([CH3:9])[CH3:10])[s:6][cH:7]1)[N:33]1[c:29]2[c:28]([c:27](-[c:24]3[cH:23][cH:22][c:21]([N:20]([CH3:19])[CH3:48])[n:26][cH:25]3)[cH:32][cH:31][cH:30]2)[C:35]2([C:34]1=[O:47])[CH2:36][O:37][c:38]1[c:39]2[cH:40][c:41]2[c:42]([cH:46]1)[O:43][CH2:44][O:45]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-576e5d02af9148e689cdfb2e681665e4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
Loading…