1-(2,4-Xylyl)piperazine → (4-Bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:12])[c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]1[F:11].[CH3:13][c:14]1[c:15]([N:21]2[CH2:22][CH2:23][NH:24][CH2:25][CH2:26]2)[cH:16][cH:17][c:18]([CH3:20])[cH:19]1>>[Br:1][c:2]1[cH:3][c:4]([Cl:12])[c:5]([C:6](=[O:8])[N:24]2[CH2:23][CH2:22][N:21]([c:15]3[c:14]([CH3:13])[cH:19][c:18]([CH3:20])[cH:17][cH:16]3)[CH2:26][CH2:25]2)[cH:9][c:10]1[F:11]Participants
3
Sources & evidence
- ORD record
- ord-ab38e68f60974645887660179ada75f1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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