Formic Acid → 2-Chloro-6-(1-methyl-piperidin-4-ylidenemethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 1142816Notes

Reaction equation

HRID 1142816 reaction equation
[CH2:27]=[O:28].[CH:24]([OH:25])=[O:26].[Cl:1][c:2]1[n:3][c:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[C:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[s:10]2.[Cl:29][c:30]1[n:31][c:32]([Cl:33])[c:34]2[o:35][cH:36][cH:37][c:38]2[n:39]1.[Cl:41][CH2:42][Cl:43].[OH2:40]>>[Cl:1][c:2]1[n:3][c:4]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)[c:5]2[c:6]([n:7]1)[cH:8][c:9]([CH:11]=[C:12]1[CH2:13][CH2:14][N:15]([CH3:24])[CH2:16][CH2:17]1)[s:10]2

Participants

7

Reactant 6

HCID 284Formic AcidHCID 712FormaldehydeHCID 962WaterHCID 6344DichloromethaneHCID 457899682,4-Dichlorofuro[3,2-D]pyrimidineHCID 866183982-Chloro-4-morpholin-4-yl-6-piperidin-4-ylidenemethyl-thieno[3,2-d]pyrimidine

Product 1

HCID 866183992-Chloro-6-(1-methyl-piperidin-4-ylidenemethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-ac8a06e1dd3044dc8aa66f0c03deee6b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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