Potassium Cation → 2,3-difluoro-5-(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazol-4-yl)pyridine

HRID 1143295Notes

Reaction equation

HRID 1143295 reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][O:45][CH2:46]1.[Cl:24][c:25]1[cH:26][c:27]([F:32])[c:28]([F:31])[n:29][cH:30]1.[K+:38].[K+:39].[K+:40].[O:1]1[CH:2]([O:7][CH2:8][CH2:9][n:10]2[n:11][cH:12][c:13]([B:15]3[O:16][C:17]([CH3:18])([CH3:19])[C:20]([CH3:21])([CH3:22])[O:23]3)[cH:14]2)[CH2:3][CH2:4][CH2:5][CH2:6]1.[OH2:47].[P:33]([O-:34])([O-:35])([O-:36])=[O:37]>>[O:1]1[CH:2]([O:7][CH2:8][CH2:9][n:10]2[n:11][cH:12][c:13](-[c:25]3[cH:26][c:27]([F:32])[c:28]([F:31])[n:29][cH:30]3)[cH:14]2)[CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 312751,4-DioxaneHCID 27832485-Chloro-2,3-difluoropyridineHCID 593418191-[2-(oxan-2-yloxy)ethyl]-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product 1

HCID 580155012,3-difluoro-5-(1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazol-4-yl)pyridine

Sources & evidence

ORD record
ord-1c6f05381aee4ebe975647a9976f220c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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