Sodium ion → Propan-2-yl 4-[[7-(2-fluoro-4-methylsulfanylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

HRID 114346Notes

Reaction equation

HRID 114346 reaction equation
[F:16][c:17]1[c:18]2[c:19]([n:20][cH:21][n:22]1)[N:23]([c:26]1[c:27]([F:34])[cH:28][c:29]([S:32][CH3:33])[cH:30][cH:31]1)[CH2:24][CH2:25]2.[H-:15].[Na+:14].[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH:11]([CH3:12])[CH3:13])[CH2:6][CH2:7]1>>[O:1]([CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][CH:11]([CH3:12])[CH3:13])[CH2:6][CH2:7]1)[c:17]1[c:18]2[c:19]([n:20][cH:21][n:22]1)[N:23]([c:26]1[c:27]([F:34])[cH:28][c:29]([S:32][CH3:33])[cH:30][cH:31]1)[CH2:24][CH2:25]2

Participants

5

Reactant 4

HCID 923Sodium ionHCID 166653HydrideHCID 16745126Isopropyl 4-Hydroxypiperidine-1-carboxylateHCID 690665884-Fluoro-7-(2-fluoro-4-methylsulfanylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidine

Product 1

HCID 58016998Propan-2-yl 4-[[7-(2-fluoro-4-methylsulfanylphenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-81af2d4bc51b41748ccdaf5ae84ee3ba
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

Loading…