Methanol → 4-Hydroxy-3-benzylpiperidine

HRID 1143480Notes

Reaction equation

HRID 1143480 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[CH:11]([OH:14])[CH2:12][CH2:13]1.[CH3:22][OH:23].[H:24][H:25].[OH-:26].[OH-:28].[Pd+2:27]>>[NH:8]1[CH2:9][CH:10]([CH2:15][c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[CH:11]([OH:14])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 230037131,3-Dibenzyl-4-hydroxypiperidineHCID 178418361HCID 178418361, compound

Product 1

HCID 230036754-Hydroxy-3-benzylpiperidine

Sources & evidence

ORD record
ord-70b489d2f058477db72b6958bda66b2b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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