4-Chlorophenylacetyl chloride → 2-(4-chloro-phenyl)-N-[(3RS,4SR)-1-(1-cyclopropylmethyl-piperidine-4-carbonyl)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-N-methyl-acetamide

HRID 1143811Notes

Reaction equation

HRID 1143811 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:6][CH2:7][CH:8]([C:11](=[O:12])[N:13]3[CH2:14][CH:15]([c:20]4[cH:21][c:22]([Cl:27])[c:23]([Cl:26])[cH:24][cH:25]4)[CH:16]([NH:18][CH3:19])[CH2:17]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3]1.[Cl:28][c:29]1[cH:30][cH:31][c:32]([CH2:35][C:36](=[O:37])[Cl:38])[cH:33][cH:34]1>>[CH:1]1([CH2:4][N:5]2[CH2:6][CH2:7][CH:8]([C:11](=[O:12])[N:13]3[CH2:14][CH:15]([c:20]4[cH:21][c:22]([Cl:27])[c:23]([Cl:26])[cH:24][cH:25]4)[CH:16]([N:18]([CH3:19])[C:36]([CH2:35][c:32]4[cH:31][cH:30][c:29]([Cl:28])[cH:34][cH:33]4)=[O:37])[CH2:17]3)[CH2:9][CH2:10]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 67025771(1-cyclopropylmethyl-piperidin-4-yl)-[(3SR,4RS)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidin-1-yl]-methanone

Product 1

HCID 670256582-(4-chloro-phenyl)-N-[(3RS,4SR)-1-(1-cyclopropylmethyl-piperidine-4-carbonyl)-4-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-N-methyl-acetamide

Sources & evidence

ORD record
ord-f905651b9453470a83b1a6dbe1f10b1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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